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1

Structure and carbohydrate analysis of the exopolysaccharide capsule of Pseudomonas putida G7

Scott C. Kachlany, Steven B. Levery, John S. Kim, Bradley L. Reuhs, Leonard W. Lion, William C. Ghiorse

Journal:

Environmental Microbiology

Year:

2001

Language:

english

File:

PDF, 733 KB

english, 2001

2

The Widespread Colonization Island of Actinobacillus actinomycetemcomitans

Planet, Paul J, Kachlany, Scott C, Fine, Daniel H, DeSalle, Rob, Figurski, David H

Journal:

Nature Genetics

Year:

2003

Language:

english

File:

PDF, 718 KB

english, 2003

3

Prophage induction in lysogenic Aggregatibacter actinomycetemcomitans cells co-cultured with human gingival fibroblasts, and its effect on leukotoxin release

Roy H. Stevens, Caroline de Moura Martins Lobo dos Santos, David Zuanazzi, Marcelo Barbosas de Accioly Mattos, Davis Fernandes Ferreira, Scott C. Kachlany, Eduardo M.B. Tinoco

Journal:

Microbial Pathogenesis

Year:

2013

Language:

english

File:

PDF, 207 KB

english, 2013

4

Significance of Wall Structure, Macromolecular Composition, and Surface Polymers to the Survival and Transport of Cryptosporidium parvum Oocysts

Jenkins, M. B., Eaglesham, B. S., Anthony, L. C., Kachlany, S. C., Bowman, D. D., Ghiorse, W. C.

Journal:

Applied and Environmental Microbiology

Year:

2010

Language:

english

File:

PDF, 1.50 MB

english, 2010

5

Aggregatibacter actinomycetemcomitans Leukotoxin Is Delivered to Host Cells in an LFA-1-Indepdendent Manner When Associated with Outer Membrane Vesicles

Nice, Justin, Balashova, Nataliya, Kachlany, Scott, Koufos, Evan, Krueger, Eric, Lally, Edward, Brown, Angela

Journal:

Year:

2018

Language:

english

File:

PDF, 4.51 MB

english, 2018

6

A bioluminescent HL-60 cell line to assay anti-leukaemia therapeutics under physiological conditions

Maria P. Isaza, Jennie T. Chau, Amy Le, Nataliya V. Balashova, Jigna K. Patel, Erica Salerno, Juan A. Crosby, Anna O'Connor, Scott C. Kachlany

Journal:

Year:

2008

Language:

english

File:

PDF, 308 KB

english, 2008

7

Anti-leukemia activity of a bacterial toxin with natural specificity for LFA-1 on white blood cells

Scott C. Kachlany, Amy B. Schwartz, Nataliya V. Balashova, Catarina E. Hioe, Michael Tuen, Amy Le, Manpreet Kaur, Yongyi Mei, Jia Rao

Journal:

Leukemia Research

Year:

2010

Language:

english

File:

PDF, 1.38 MB

english, 2010

8

flp-1, the first representative of a new pilin gene subfamily, is required for non-specific adherence of Actinobacillus actinomycetemcomitans

Scott C. Kachlany, Paul J. Planet, Rob DeSalle, Daniel H. Fine, David H. Figurski, Jeffrey B. Kaplan

Journal:

Molecular Microbiology

Year:

2001

Language:

english

File:

PDF, 720 KB

english, 2001

9

How we got attached to Actinobacillus actinomycetemcomitans: a model for infectious diseases

Daniel H. Fine, Jeffrey B. Kaplan, Scott C. Kachlany, Helen C. Schreiner

Journal:

Periodontology 2000

Year:

2006

Language:

english

File:

PDF, 1.63 MB

english, 2006

10

In vitro synergism between LFA-1 targeting leukotoxin (Leukothera™) and standard chemotherapeutic agents in leukemia cells

Anukriti Gupta, Amy Le, Benjamin A. Belinka, Scott C. Kachlany

Journal:

Leukemia Research

Year:

2011

Language:

english

File:

PDF, 1.88 MB

english, 2011

11

TdeA, a TolC-like protein required for toxin and drug export in Aggregatibacter (Actinobacillus) actinomycetemcomitans

Juan A. Crosby, Scott C. Kachlany

Journal:

Year:

2007

Language:

english

File:

PDF, 529 KB

english, 2007

12

Aggregatibacter actinomycetemcomitans LtxC is required for leukotoxin activity and initial interaction between toxin and host cells

Nataliya V. Balashova, Chintan Shah, Jigna K. Patel, Susie Megalla, Scott C. Kachlany

Journal:

Year:

2009

Language:

english

File:

PDF, 572 KB

english, 2009

13

Characterization of leukotoxin from a clinical strain of Actinobacillus actinomycetemcomitans

Roger Diaz, Lourdes Al Ghofaily, Jigna Patel, Nataliya V. Balashova, Anna C. Freitas, Irene Labib, Scott C. Kachlany

Journal:

Microbial Pathogenesis

Year:

2006

Language:

english

File:

PDF, 213 KB

english, 2006

14

Both leukotoxin and poly-N-acetylglucosamine surface polysaccharide protect Aggregatibacter actinomycetemcomitans cells from macrophage killing

Vishwanath Venketaraman, Albert K. Lin, Amy Le, Scott C. Kachlany, Nancy D. Connell, Jeffrey B. Kaplan

Journal:

Microbial Pathogenesis

Year:

2008

Language:

english

File:

PDF, 2.38 MB

english, 2008

15

Cytotoxic effects of Kingella kingae outer membrane vesicles on human cells

R. Maldonado, R. Wei, S.C. Kachlany, M. Kazi, N.V. Balashova

Journal:

Microbial Pathogenesis

Year:

2011

Language:

english

File:

PDF, 896 KB

english, 2011

16

Genes for tight adherence of Actinobacillus actinomycetemcomitans: from plaque to plague to pond scum

Scott C. Kachlany, Paul J. Planet, Rob DeSalle, Daniel H. Fine, David H. Figurski

Journal:

Trends in Microbiology

Year:

2001

Language:

english

File:

PDF, 101 KB

english, 2001

17

Purification of secreted leukotoxin (LtxA) from Actinobacillus actinomycetemcomitans

Scott C Kachlany, Daniel H Fine, David H Figurski

Journal:

Protein Expression and Purification

Year:

2002

Language:

english

File:

PDF, 194 KB

english, 2002

18

Effects of Aggregatibacter actinomycetemcomitans leukotoxin on endothelial cells

Dietmann, Anelia, Millonig, Alban, Combes, Valery, Couraud, Pierre-Olivier, Kachlany, Scott C., Grau, Georges E.

Journal:

Microbial Pathogenesis

Year:

2013

Language:

english

File:

PDF, 1.29 MB

english, 2013

19

Human CD18 Is the Functional Receptor for Aggregatibacter actinomycetemcomitans Leukotoxin

Dileepan, T., Kachlany, S. C., Balashova, N. V., Patel, J., Maheswaran, S. K.

Journal:

Infection and Immunity

Year:

2007

Language:

english

File:

PDF, 283 KB

english, 2007

20

Nonspecific Adherence by Actinobacillus actinomycetemcomitans Requires Genes Widespread in Bacteria and Archaea

Kachlany, S. C., Planet, P. J., Bhattacharjee, M. K., Kollia, E., DeSalle, R., Fine, D. H., Figurski, D. H.

Journal:

Journal of Bacteriology

Year:

2000

Language:

english

File:

PDF, 2.21 MB

english, 2000

21

Expression and targeting of lymphocyte function-associated antigen 1 (LFA-1) on white blood cells for treatment of allergic asthma

Gupta, A., Espinosa, V., Galusha, L. E., Rahimian, V., Miro, K. L., Rivera-Medina, A., Kasinathan, C., Capitle, E., Aguila, H. A., Kachlany, S. C.

Journal:

Journal of Leukocyte Biology

Year:

2015

Language:

english

File:

PDF, 1.79 MB

english, 2015

22

Aggregatibacter actinomycetemcomitans leukotoxin (LtxA; Leukothera) induces cofilin dephosphorylation and actin depolymerization during killing of malignant monocytes

Kaur, M., Kachlany, S. C.

Journal:

Microbiology (Society for General Microbiology)

Year:

2014

Language:

english

File:

PDF, 821 KB

english, 2014

23

Leukotoxin (Leukothera(R)) Targets Active Leukocyte Function Antigen-1 (LFA-1) Protein and Triggers a Lysosomal Mediated Cell Death Pathway

DiFranco, K. M., Gupta, A., Galusha, L. E., Perez, J., Nguyen, T.-V. K., Fineza, C. D., Kachlany, S. C.

Journal:

Journal of Biological Chemistry

Year:

2012

Language:

english

File:

PDF, 2.94 MB

english, 2012

24

Phylogeny of genes for secretion NTPases: Identification of the widespread tadA subfamily and development of a diagnostic key for gene classification

Planet, P. J., Kachlany, S. C., DeSalle, R., Figurski, D. H.

Journal:

Proceedings of the National Academy of Sciences

Year:

2001

Language:

english

File:

PDF, 254 KB

english, 2001

25

Tight-adherence genes of Actinobacillus actinomycetemcomitans are required for virulence in a rat model

Schreiner, H. C., Sinatra, K., Kaplan, J. B., Furgang, D., Kachlany, S. C., Planet, P. J., Perez, B. A., Figurski, D. H., Fine, D. H.

Journal:

Proceedings of the National Academy of Sciences

Year:

2003

Language:

english

File:

PDF, 171 KB

english, 2003

26

Significance of Wall Structure, Macromolecular Composition, and Surface Polymers to the Survival and Transport of Cryptosporidium parvum Oocysts

Jenkins, M. B., Eaglesham, B. S., Anthony, L. C., Kachlany, S. C., Bowman, D. D., Ghiorse, W. C.

Journal:

Applied and Environmental Microbiology

Year:

2010

File:

PDF, 18 KB

2010

27

Genome Sequence of Kingella kingae Septic Arthritis Isolate PYKK081

Kaplan, J. B., Lo, C., Xie, G., Johnson, S. L., Chain, P. S. G., Donnelly, R., Kachlany, S. C., Balashova, N. V.

Journal:

Journal of Bacteriology

Year:

2012

Language:

english

File:

PDF, 83 KB

english, 2012

28

Regulation of Aggregatibacter (Actinobacillus) actinomycetemcomitans Leukotoxin Secretion by Iron

Balashova, N. V., Diaz, R., Balashov, S. V., Crosby, J. A., Kachlany, S. C.

Journal:

Journal of Bacteriology

Year:

2006

Language:

english

File:

PDF, 78 KB

english, 2006

29

Genetic Analysis of the Requirement for flp-2, tadV, and rcpB in Actinobacillus actinomycetemcomitans Biofilm Formation

Perez, B. A., Planet, P. J., Kachlany, S. C., Tomich, M., Fine, D. H., Figurski, D. H.

Journal:

Journal of Bacteriology

Year:

2006

Language:

english

File:

PDF, 656 KB

english, 2006

30

Aggregatibacter actinomycetemcomitans Leukotoxin: from Threat to Therapy

Kachlany, S. C.

Journal:

Journal of Dental Research

Year:

2010

Language:

english

File:

PDF, 295 KB

english, 2010

31

Interaction between Leukotoxin and Cu,Zn Superoxide Dismutase in Aggregatibacter actinomycetemcomitans

Balashova, N. V., Park, D. H., Patel, J. K., Figurski, D. H., Kachlany, S. C.

Journal:

Infection and Immunity

Year:

2007

Language:

english

File:

PDF, 409 KB

english, 2007

32

Secretion of RTX Leukotoxin by Actinobacillus actinomycetemcomitans

Kachlany, S. C., Fine, D. H., Figurski, D. H.

Journal:

Infection and Immunity

Year:

2000

Language:

english

File:

PDF, 2.13 MB

english, 2000

33

Aggregatibacter actinomycetemcomitans Leukotoxin Utilizes a Cholesterol Recognition/Amino Acid Consensus Site for Membrane Association

Brown, A. C., Balashova, N. V., Epand, R. M., Epand, R. F., Bragin, A., Kachlany, S. C., Walters, M. J., Du, Y., Boesze-Battaglia, K., Lally, E. T.

Journal:

Journal of Biological Chemistry

Year:

2013

Language:

english

File:

PDF, 3.03 MB

english, 2013

34

Broad-Spectrum Biofilm Inhibition by Kingella kingae Exopolysaccharide

Bendaoud, M., Vinogradov, E., Balashova, N. V., Kadouri, D. E., Kachlany, S. C., Kaplan, J. B.

Journal:

Journal of Bacteriology

Year:

2011

Language:

english

File:

PDF, 1.15 MB

english, 2011

35

Screen for Leukotoxin Mutants in Aggregatibacter actinomycetemcomitans: Genes of the Phosphotransferase System Are Required for Leukotoxin Biosynthesis

Isaza, M. P., Duncan, M. S., Kaplan, J. B., Kachlany, S. C.

Journal:

Infection and Immunity

Year:

2008

Language:

english

File:

PDF, 569 KB

english, 2008

36

Gangliosides Block Aggregatibacter Actinomycetemcomitans Leukotoxin (LtxA)-Mediated Hemolysis

Forman, Michael S., Nishikubo, Jason B., Han, Rebecca K., Le, Amy, Balashova, Nataliya V., Kachlany, Scott C.

Journal:

Year:

2010

Language:

english

File:

PDF, 318 KB

english, 2010

37

Nonspecific Adherence and Fibril Biogenesis by Actinobacillus actinomycetemcomitans: TadA Protein Is an ATPase

Bhattacharjee, M. K., Kachlany, S. C., Fine, D. H., Figurski, D. H.

Journal:

Journal of Bacteriology

Year:

2001

Language:

english

File:

PDF, 746 KB

english, 2001

38

Resolution of Psoriasis by a Leukocyte-Targeting Bacterial Protein in a Humanized Mouse Model

Stenderup, Karin, Rosada, Cecilia, Dam, Thomas N, Salerno, Erica, Belinka, Benjamin A, Kachlany, Scott C

Journal:

The Journal of Investigative Dermatology

Year:

2011

Language:

english

File:

PDF, 858 KB

english, 2011

39

Mechanisms of LtxA (Leukotoxin), a Potent New Anti-Inflammatory Agent for the Treatment of Alopecia Areata

Kachlany, Scott C

Journal:

JID Symposium Proceedings

Year:

2015

Language:

english

File:

PDF, 364 KB

english, 2015

40

LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes

DiFranco, Kristina M., Johnson-Farley, Nadine, Bertino, Joseph R., Elson, David, Vega, Brian A., Belinka, Benjamin A., Kachlany, Scott C.

Journal:

Leukemia Research

Year:

2015

Language:

english

File:

PDF, 1.84 MB

english, 2015

41

D3 HIV Envelope gp120 Activates LFA-1 on CD4 T-Lymphocytes and Increases Cell Susceptibility to LFA-1-Targeting Leukotoxin (LtxA)

Hioe, C. E., Tuen, M., Vasiliver-Shamis, G., Alvarez, Y., Prins, K. C., Banarjee, S., Nadas, A., Cho, M. W., Dustin, M. L., Kachlany, S. C.

Journal:

JAIDS Journal of Acquired Immune Deficiency Syndromes

Year:

2012

Language:

english

File:

PDF, 1.53 MB

english, 2012

42

Leukotoxin Confers Beta-Hemolytic Activity to Actinobacillus actinomycetemcomitans

Balashova, N. V., Crosby, J. A., Al Ghofaily, L., Kachlany, S. C.

Journal:

Infection and Immunity

Year:

2006

Language:

english

File:

PDF, 210 KB

english, 2006

43

Structural Proteins of Enterococcus faecalis bacteriophage φEf11

Stevens, Roy H., Zhang, Hongming, Hsiao, Chaiwing, Kachlany, Scott, Tinoco, Eduardo M. B., DePew, Jessica, Fouts, Derrick E.

Journal:

Year:

2016

Language:

english

File:

PDF, 886 KB

english, 2016

44

Selective Targeting of High-Affinity LFA-1 Does Not Augment Costimulation Blockade in a Nonhuman Primate Renal Transplantation Model

Samy, K. P., Anderson, D. J., Lo, D. J., Mulvihill, M. S., Song, M., Farris, A. B., Parker, B. S., MacDonald, A. L., Lu, C., Springer, T. A., Kachlany, S. C., Reimann, K. A., How, T., Leopardi, F. V.,

Journal:

American Journal of Transplantation

Year:

2017

Language:

english

File:

PDF, 2.10 MB

english, 2017

45

HIV Envelope gp120 Activates LFA-1 on CD4 T-Lymphocytes and Increases Cell Susceptibility to LFA-1-Targeting Leukotoxin (LtxA)

Hioe, Catarina E., Tuen, Michael, Vasiliver-Shamis, Gaia, Alvarez, Yelina, Prins, Kathleen C., Banerjee, Sagarika, Nádas, Arthur, Cho, Michael W., Dustin, Michael L., Kachlany, Scott C., Badley, Andre

Journal:

Year:

2011

Language:

english

File:

PDF, 2.30 MB

english, 2011

46

Aggregatibacter actinomycetemcomitans leukotoxin (LtxA; Leukothera®) requires death receptor Fas, in addition to LFA-1, to trigger cell death in T lymphocytes

Vega, Brian A., Schober, Liam T., Kim, Tami, Belinka, Benjamin A., Kachlany, Scott C.

Journal:

Infection and Immunity

Year:

2019

Language:

english

File:

PDF, 1.68 MB

english, 2019

47

Aggregatibacter actinomycetemcomitans leukotoxin (LtxA; Leukothera®) requires death receptor Fas, in addition to LFA-1, to trigger cell death in T lymphocytes

Vega, Brian A., Schober, Liam T., Kim, Tami, Belinka, Benjamin A., Kachlany, Scott C.

Journal:

Infection and Immunity

Year:

2019

File:

PDF, 1.68 MB

2019

48

Aggregatibacter actinomycetemcomitans Leukotoxin (LtxA; Leukothera®): Mechanisms of Action and Therapeutic Applications

Vega, Brian A., Belinka Jr., Benjamin A., Kachlany, Scott C.

Journal:

Year:

2019

Language:

english

File:

PDF, 1.03 MB

english, 2019

49

Leukotoxin Selectively Kills NK and Effector Memory T Cells.

Anderson, D., Lo, D., Strobert, E., Kachlany, S., Larsen, C., Kirk, A.

Journal:

Transplantation Journal

Year:

2014

File:

PDF, 199 KB

2014

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